UniProt:Q6L506 RIBA3

chain
  • transit peptide:1-43
  • chain:44-536
checksum 563F9C7C0A4B4A05
comment
  • FUNCTION Involved in riboflavin biosynthesis. Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity).CATALYTIC ACTIVITY GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)COFACTOR Binds 1 zinc ion per subunit.PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.SUBCELLULAR LOCATION In the N-terminal section; belongs to the DHBP synthase family.SIMILARITY In the C-terminal section; belongs to the GTP cyclohydrolase II family.CAUTION The substrate-binding sites for the inactive DHBP synthase activity are conserved while several cofactor-binding sites are lost.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1158777
description
  • recommendedName: Probable monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic domain recommendedName: Inactive 3,4-dihydroxy-2-butanone 4-phosphate synthase shortName: DHBP synthase /domain domain recommendedName: GTP cyclohydrolase-2 ecNumber: 3.5.4.25 alternativeName: GTP cyclohydrolase II /domain
displayName UniProt:Q6L506 RIBA3
geneName
  • RIBA3
  • Os05g0460600
  • OJ1281_H05.8
  • OsJ_18816
identifier Q6L506
isSequenceChanged false
keyword
  • Chloroplast
  • GTP-binding
  • Hydrolase
  • Metal-binding
  • Nucleotide-binding
  • Plastid
  • Reference proteome
  • Riboflavin biosynthesis
  • Transit peptide
  • Zinc
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • RIBA3
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RIBA3_ORYSJ
  • A0A0P0WNE0
  • Q84PC2
sequenceLength 536
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6L506