UniProt:Q6Z3A3 GSH1-2

chain
  • transit peptide:1-34
  • chain:35-496
checksum A232857B83631A75
comment
  • CATALYTIC ACTIVITY L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)PATHWAY Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.SUBUNIT Homodimer or monomer when oxidized or reduced, respectively.SUBCELLULAR LOCATION The Cys-160-Cys-380 disulfide bridge is known to modulate the enzyme activity according to the redox status. The oxidized form constitutes the active enzyme (By similarity).SIMILARITY Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1158030
description
  • recommendedName: Glutamate--cysteine ligase B, chloroplastic ecNumber: 6.3.2.2 alternativeName: Gamma-ECS B shortName: GCS B alternativeName: Gamma-glutamylcysteine synthetase B
displayName UniProt:Q6Z3A3 GSH1-2
geneName
  • GSH1-2
  • Os07g0462000
  • LOC_Os07g27790
  • P0038F09.39
identifier Q6Z3A3
isSequenceChanged false
keyword
  • ATP-binding
  • Chloroplast
  • Disulfide bond
  • Glutathione biosynthesis
  • Ligase
  • Nucleotide-binding
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • GSH1-2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GSH1B_ORYSJ
  • A3BJG6
  • Q0D6N0
sequenceLength 496
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6Z3A3