UniProt:Q336M7 4CLL2

chain
  • chain:1-583
checksum F707063E656431BA
comment
  • FUNCTION Carboxylate--CoA ligase that may use 4-coumarate as substrate. Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.CATALYTIC ACTIVITY (E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY (E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphateCATALYTIC ACTIVITY (E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)COFACTOR Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1158024
description
  • recommendedName: 4-coumarate--CoA ligase-like 2 ecNumber evidence="1"6.2.1.12
displayName UniProt:Q336M7 4CLL2
geneName
  • 4CLL2
  • Os10g0578950
  • LOC_Os10g42800
  • OsJ_031306
  • OSJNBa0056G17.30
identifier Q336M7
isSequenceChanged false
keyword
  • ATP-binding
  • Ligase
  • Magnesium
  • Nucleotide-binding
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • 4CLL2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 4CLL2_ORYSJ
  • A3C7N4
  • Q9FRQ0
sequenceLength 583
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q336M7