UniProt:Q10P67 DAPB2

chain
  • transit peptide:1-32
  • chain:33-325
checksum E1A4D87189A0585F
comment
  • FUNCTION Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.SUBCELLULAR LOCATION Belongs to the DapB family.CAUTION Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1157949
description
  • recommendedName: Probable 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic shortName: HTPA reductase 2 ecNumber: 1.17.1.8
displayName UniProt:Q10P67 DAPB2
geneName
  • DAPB2
  • Os03g0245100
  • LOC_Os03g14120
  • OsJ_009732
  • OsJ_10116
identifier Q10P67
isSequenceChanged false
keyword
  • Alternative splicing
  • Amino-acid biosynthesis
  • Chloroplast
  • Diaminopimelate biosynthesis
  • Lysine biosynthesis
  • NAD
  • NADP
  • Oxidoreductase
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • DAPB2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DAPB2_ORYSJ
  • A3AG10
  • B7ESW8
  • Q0DTI8
  • Q10P66
sequenceLength 325
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q10P67