UniProt:Q6K8J4 ISPG

chain
  • transit peptide:1-39
  • chain:40-744
checksum 6BE6F2134FC0604F
comment
  • FUNCTION Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development (By similarity).CATALYTIC ACTIVITY (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + H(+)COFACTOR Binds 1 [4Fe-4S] cluster per subunit.PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.SUBUNIT Homodimer.SUBCELLULAR LOCATION Belongs to the IspG family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1156847
description
  • recommendedName: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic ecNumber: 1.17.7.1 alternativeName: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
displayName UniProt:Q6K8J4 ISPG
geneName
  • ISPG
  • Os02g0603800
  • LOC_Os02g39160
  • OJ1669_F01.30
  • OsJ_07430
identifier Q6K8J4
isSequenceChanged false
keyword
  • 4Fe-4S
  • Chloroplast
  • Iron
  • Iron-sulfur
  • Isoprene biosynthesis
  • Metal-binding
  • Oxidoreductase
  • Plastid
  • Reference proteome
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • ISPG
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ISPG_ORYSJ
  • A0A0P0VLD4
  • Q84PA7
sequenceLength 744
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6K8J4