UniProt:Q10CE4 GLO1

chain
  • chain:1-369
checksum B14AF6A0E95883FF
comment
  • FUNCTION Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2 (PubMed:16595582). Is a key enzyme in photorespiration in plants (By similarity). To a lesser extent, is also able to oxidize glyoxylate to oxalate in vitro (PubMed:16595582). Can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase (PubMed:19264754). Does not seem to play a role in oxalate accumulation (PubMed:16595582).CATALYTIC ACTIVITY glycolate + O2 = glyoxylate + H2O2COFACTOR Competitively inhibited by oxalate.BIOPHYSICOCHEMICAL PROPERTIES Photosynthesis; photorespiration; glycine from 2-phosphoglycolate: step 2/3.SUBUNIT Homotetramer (By similarity). Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes. Binds to CATB and CATC; these interactions are disturbed by alpha-hydroxy-2-pyridinemethanesulfonic acid (HPMS) and salicylic acid (SA) (PubMed:26900141).SUBCELLULAR LOCATION Expressed constitutively in leaves (at protein level).SIMILARITY Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1156522
description
  • recommendedName: Glycolate oxidase 1 shortName: GOX 1 shortName: OsGLO1 ecNumber evidence="6"1.1.3.15 alternativeName: Peroxisomal (S)-2-hydroxy-acid oxidase GLO1 alternativeName: Short chain alpha-hydroxy acid oxidase GLO1
displayName UniProt:Q10CE4 GLO1
geneName
  • GLO1
  • GOX
  • Os03g0786100
  • LOC_Os03g57220
  • OsJ_12861
identifier Q10CE4
isSequenceChanged false
keyword
  • Flavoprotein
  • FMN
  • Glycolate pathway
  • Host-virus interaction
  • Oxidoreductase
  • Peroxisome
  • Photorespiration
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • GLO1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GLO1_ORYSJ
  • A0A0P0W4I1
sequenceLength 369
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q10CE4