UniProt:O22567 CLA1

chain
  • transit peptide:1-51
  • chain:52-720
checksum FB70C11EAF6C8BB5
comment
  • FUNCTION Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP). Is a limiting enzyme for plastidic isoprenoid biosynthesis and essential for chloroplast development (By similarity).CATALYTIC ACTIVITY D-glyceraldehyde 3-phosphate + pyruvate + H(+) = 1-deoxy-D-xylulose 5-phosphate + CO2COFACTOR Binds 1 Mg(2+) ion per subunit.COFACTOR Binds 1 thiamine pyrophosphate per subunit.PATHWAY Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.SUBUNIT Homodimer.SUBCELLULAR LOCATION By the mycorrhizal fungus G.intraradices colonization in roots.SIMILARITY Belongs to the transketolase family. DXPS subfamily.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1156285
description
  • recommendedName: 1-deoxy-D-xylulose-5-phosphate synthase 1, chloroplastic shortName: 1-deoxyxylulose-5-phosphate synthase shortName: DXP synthase shortName: DXPS ecNumber: 2.2.1.7
displayName UniProt:O22567 CLA1
geneName
  • CLA1
  • Os05g0408900
  • LOC_Os05g33840
  • OSJNBb0014K18.8
  • P0040B10.17
identifier O22567
isSequenceChanged false
keyword
  • Alternative splicing
  • Chloroplast
  • Isoprene biosynthesis
  • Magnesium
  • Metal-binding
  • Plastid
  • Reference proteome
  • Thiamine biosynthesis
  • Thiamine pyrophosphate
  • Transferase
  • Transit peptide
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • CLA1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DXS1_ORYSJ
  • A0A0P0WM75
  • Q0DI85
  • Q5TKB6
  • Q6I573
sequenceLength 720
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/O22567