UniProt:O04226 Os05g0455500

chain
  • chain:1-716
checksum F8D3C7D9449CFA64
comment
  • FUNCTION P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants. Involved in abiotic stress tolerance.CATALYTIC ACTIVITY L-glutamate + ATP = L-glutamyl 5-phosphate + ADPCATALYTIC ACTIVITY L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)ACTIVITY REGULATION Feedback regulated by proline.PATHWAY Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.PATHWAY Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.TISSUE SPECIFICITY Expressed at high levels in leaves.INDUCTION Induced by salt, drought and cold stresses, and abscisic acid (ABA).MISCELLANEOUS Tobacco plants over-expressing P5CS1 and P5CS2 have elevated proline levels and display enhanced abiotic stress tolerance.SIMILARITY In the N-terminal section; belongs to the glutamate 5-kinase family.SIMILARITY In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1156025
description
  • recommendedName: fullName evidence="7"Delta-1-pyrroline-5-carboxylate synthase 1 shortName evidence="6"OsP5CS1 domain recommendedName: Glutamate 5-kinase shortName: GK ecNumber: 2.7.2.11 alternativeName: Gamma-glutamyl kinase /domain domain recommendedName: Gamma-glutamyl phosphate reductase shortName: GPR ecNumber: 1.2.1.41 alternativeName: Glutamate-5-semialdehyde dehydrogenase alternativeName: Glutamyl-gamma-semialdehyde dehydrogenase /domain
displayName UniProt:O04226 Os05g0455500
geneName
  • Os05g0455500
  • P5CS
  • LOC_Os05g38150
  • OJ1651_D06.9
  • P5CS1
identifier O04226
isSequenceChanged false
keyword
  • Amino-acid biosynthesis
  • ATP-binding
  • Kinase
  • Multifunctional enzyme
  • NADP
  • Nucleotide-binding
  • Oxidoreductase
  • Proline biosynthesis
  • Reference proteome
  • Stress response
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • P5CS1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • P5CS1_ORYSJ
  • Q0DHN6
  • Q60EM4
  • Q6PW76
sequenceLength 716
species [Species:186860] Oryza sativa
url http://purl.uniprot.org/uniprot/O04226