UniProt:Q6ZHS4 CAD2

chain
  • chain:1-363
checksum EFD21231AFB35B4B
comment
  • FUNCTION Involved in lignin biosynthesis (PubMed:16443696, PubMed:21912859). Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde and sinapaldehyde to their respective alcohols (PubMed:16443696). Plays the major role in monolignol biosynthesis. Functions cooperatively with COMT in the culm internodes for the biosynthesis of monolignols, the lignin precursors. May be involved in lignin biosynthesis in leaves and roots (PubMed:21912859).CATALYTIC ACTIVITY (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+)COFACTOR Binds 2 Zn(2+) ions per subunit.BIOPHYSICOCHEMICAL PROPERTIES Aromatic compound metabolism; phenylpropanoid biosynthesis.SUBUNIT Homodimer.TISSUE SPECIFICITY Expressed in roots behind the root tips in the pericycle region and layer of cortical cells adjacent to the exodermis. Expressed in vascular bundles and lateral veins of leaf sheaths and blades. Expressed in the vicinity of vascular bundles in the first internode below the inflorescence (PubMed:15452707, PubMed:16443696). Highly expressed in the culm (PubMed:21912859).DISRUPTION PHENOTYPE Reduced lignin content, reddish-brown coloration of panicles and internodes, and golden yellow seeds.SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1155594
description
  • recommendedName: fullName evidence="7"Cinnamyl alcohol dehydrogenase 2 shortName evidence="5"OsCAD2 ecNumber evidence="3"1.1.1.195 alternativeName: fullName evidence="6"Protein GOLD HULL AND INTERNODE 2
displayName UniProt:Q6ZHS4 CAD2
geneName
  • CAD2
  • CAD
  • GH2
  • Os02g0187800
  • LOC_Os02g09490
  • OJ1073_F05.31
  • OJ1145_F01.6
identifier Q6ZHS4
isSequenceChanged false
keyword
  • Lignin biosynthesis
  • Metal-binding
  • NADP
  • Oxidoreductase
  • Reference proteome
  • Zinc
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • CAD2
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CADH2_ORYSJ
  • A0A0N7KEU2
  • Q75W59
sequenceLength 363
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6ZHS4