UniProt:Q5Z856 ADCS

chain
  • transit peptide:1-48
  • chain:49-895
checksum 81F2E03ADA520040
comment
  • FUNCTION Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity (By similarity).CATALYTIC ACTIVITY chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamatePATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.PATHWAY Antibiotic biosynthesis; candicidin biosynthesis.SUBCELLULAR LOCATION The PABA component provides the glutamine amidotransferase activity.DOMAIN The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.SIMILARITY In the C-terminal section; belongs to the anthranilate synthase component I family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
crossReference
databaseName UniProt
dbId 1155453
description
  • recommendedName: Probable aminodeoxychorismate synthase, chloroplastic shortName: ADC synthase ecNumber: 2.6.1.85 alternativeName: P-aminobenzoic acid synthase shortName: PABA synthase alternativeName: Para-aminobenzoate synthase
displayName UniProt:Q5Z856 ADCS
geneName
  • ADCS
  • Os06g0699700
  • LOC_Os06g48620
  • P0468G03.14
identifier Q5Z856
isSequenceChanged false
keyword
  • Chloroplast
  • Folate biosynthesis
  • Glutamine amidotransferase
  • Multifunctional enzyme
  • Plastid
  • Reference proteome
  • Transferase
  • Transit peptide
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name
  • ADCS
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ADCS_ORYSJ
  • Q0D9T5
sequenceLength 895
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q5Z856