UniProt:Q6ZJK7 TDC1

chain
  • chain:1-514
checksum C72C94D1A5485FE9
comment
  • FUNCTION Involved in serotonin biosynthesis (PubMed:17763868, PubMed:19439571, PubMed:32595985). Catalyzes the decarboxylation of L-tryptophan to produce tryptamine, which is converted to serotonin by tryptamine 5-hydroxylase (PubMed:17763868, PubMed:32595985). May play a major role in serotonin biosynthesis during senescence (PubMed:19439571). Accumulation of serotonin attenuates leaf senescence (PubMed:19439571). Catalyzes the decarboxylation of 5-hydroxy-L-tryptophan to produce serotonin (PubMed:32595985).CATALYTIC ACTIVITY L-tryptophan + H(+) = tryptamine + CO2CATALYTIC ACTIVITY 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2COFACTOR Forms homodimers.INDUCTION Induced by senescence and abscisic acid (ABA).SIMILARITY Belongs to the group II decarboxylase family.
created [InstanceEdit:1164949] Wu, Guanming, 2010-12-11
databaseName UniProt
dbId 1155245
description
  • recommendedName: fullName evidence="5"Tryptophan decarboxylase 1 ecNumber evidence="2 4"4.1.1.28 alternativeName: fullName evidence="6"5-hydroxytryptophan decarboxylase TDC1
displayName UniProt:Q6ZJK7 TDC1
geneName
  • TDC1
  • Os08g0140300
  • LOC_Os08g04540
  • OJ1368_G08.14
  • OsJ_25993
identifier Q6ZJK7
isSequenceChanged false
keyword
  • 3D-structure
  • Decarboxylase
  • Lyase
  • Pyridoxal phosphate
  • Reference proteome
  • Serotonin biosynthesis
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name
  • TDC1
referenceDatabase [ReferenceDatabase:2] UniProt
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TDC1_ORYSJ
sequenceLength 514
species [Species:1250427] Oryza sativa subsp. japonica
url http://purl.uniprot.org/uniprot/Q6ZJK7