KDSR

Stable Identifier
R-OSA-9025500
Type
Protein [EntityWithAccessionedSequence]
Species
Oryza sativa
Synonyms
3-keto dihydro sphinganine reductase
Locations in the PathwayBrowser
Expand all
Summation

KDSR (3-ketodihydrosphingosine reductase) enzyme associated with the cytosolic face of the endoplasmic reticulum membrane catalyzes the reduction of 3-ketosphingoid by NADPH to form sphingoid (Kihara and Igarashi 2004). Defects in KDSR or missing activity causes Erythrokeratodermia (EKVP4, MIM:617526), associated with sphingolipid dysregulation (Boyden et al., 2017). While there is no data on substrates other than 3-ketosphinganine, it is probable that KDSR has activity toward 3-ketosphingoids with other chain lengths than C16.

Literature References
External Reference Information
External Reference
UniProt:Q6ZHJ6 Os02g0701900
Gene Names
Os02g0701900, OJ1218_D07.5, OsJ_08059, OSNPB_020701900
Inferred To
CCACVL1_23642 [endoplasmic reticulum membrane] (Corchorus capsularis)
CCACVL1_23641 [endoplasmic reticulum membrane] (Corchorus capsularis)
HanXRQr2_Chr01g0041501 [endoplasmic reticulum membrane] (Helianthus annuus)
TRIDC6AG041470 [endoplasmic reticulum membrane] (Triticum dicoccoides)
scaffold279.128 [endoplasmic reticulum membrane] (Echinochloa crus-galli)
C5167_043493 [endoplasmic reticulum membrane] (Papaver somniferum)
BjuB01g01510S [endoplasmic reticulum membrane] (Brassica juncea)
TRITD6Av1G171170 [endoplasmic reticulum membrane] (Triticum turgidum)
TraesCS6D02G245000 [endoplasmic reticulum membrane] (Triticum aestivum)
Csa19g008710 [endoplasmic reticulum membrane] (Camelina sativa)
AT5G19200 [endoplasmic reticulum membrane] (Arabidopsis thaliana)
Zm00001eb188220 [endoplasmic reticulum membrane] (Zea mays ver5)
FCD_00033007 [endoplasmic reticulum membrane] (Ficus carica)
gene-BT93_B0839 [endoplasmic reticulum membrane] (Corymbia citriodora)
scaffold279.127 [endoplasmic reticulum membrane] (Echinochloa crus-galli)
QL06p003747 [endoplasmic reticulum membrane] (Quercus lobata)
BRADI_3g52570v3 [endoplasmic reticulum membrane] (Brachypodium distachyon)
HanXRQr2_Chr10g0427291 [endoplasmic reticulum membrane] (Helianthus annuus)
ONIVA02G31980 [endoplasmic reticulum membrane] (Oryza nivara)
GSBRNA2T00154331001 [endoplasmic reticulum membrane] (Brassica napus)
Vfaba.Hedin2.R1.1g454720 [endoplasmic reticulum membrane] (Vicia faba var. faba)
GSBRNA2T00120039001 [endoplasmic reticulum membrane] (Brassica napus)
Bo5g144810 [endoplasmic reticulum membrane] (Brassica oleracea)
TuG1812G0600002991.01 [endoplasmic reticulum membrane] (Triticum urartu)
scaffold122.102 [endoplasmic reticulum membrane] (Echinochloa crus-galli)
Csa20g028800 [endoplasmic reticulum membrane] (Camelina sativa)
EVM0018827 [endoplasmic reticulum membrane] (Pistacia vera)
SIN_1010066 [endoplasmic reticulum membrane] (Sesamum indicum)
BjuB02g35830S [endoplasmic reticulum membrane] (Brassica juncea)
gene-CFP56_02071 [endoplasmic reticulum membrane] (Quercus suber)
CCACVL1_21662 [endoplasmic reticulum membrane] (Corchorus capsularis)
RchiOBHm_Chr6g0272881 [endoplasmic reticulum membrane] (Rosa chinensis)
SETIT_017776mg [endoplasmic reticulum membrane] (Setaria italica)
HanXRQr2_Chr11g0516271 [endoplasmic reticulum membrane] (Helianthus annuus)
OBART02G29200 [endoplasmic reticulum membrane] (Oryza barthii)
CCACVL1_17178 [endoplasmic reticulum membrane] (Corchorus capsularis)
TRITD6Bv1G158130 [endoplasmic reticulum membrane] (Triticum turgidum)
EUGRSUZ_B01114 [endoplasmic reticulum membrane] (Eucalyptus grandis)
TRIDC6BG048370 [endoplasmic reticulum membrane] (Triticum dicoccoides)
itb13g23200 [endoplasmic reticulum membrane] (Ipomoea triloba)
TraesTSP6D01G265400 [endoplasmic reticulum membrane] (Triticum spelta subsp. spelta)
CCACVL1_02232 [endoplasmic reticulum membrane] (Corchorus capsularis)
GSCOC_T00026010001 [endoplasmic reticulum membrane] (Coffea canephora)
RchiOBHm_Chr4g0417501 [endoplasmic reticulum membrane] (Rosa chinensis)
TraesTSP6B01G319300 [endoplasmic reticulum membrane] (Triticum spelta subsp. spelta)
DRNTG_07901 [endoplasmic reticulum membrane] (Dioscorea rotundata)
PHAVU_006G152000g [endoplasmic reticulum membrane] (Phaseolus vulgaris)
TraesTSP6A01G251300 [endoplasmic reticulum membrane] (Triticum spelta subsp. spelta)
TanjilG_09326 [endoplasmic reticulum membrane] (Lupinus angustifolius)
TCM_020543 [endoplasmic reticulum membrane] (Theobroma cacao)
TCM_020544 [endoplasmic reticulum membrane] (Theobroma cacao)
PRUPE_6G171900 [endoplasmic reticulum membrane] (Prunus persica)
PGSC0003DMG401011813 [endoplasmic reticulum membrane] (Solanum tuberosum)
AUR62042438 [endoplasmic reticulum membrane] (Chenopodium quinoa)
A4A49_21552 [endoplasmic reticulum membrane] (Nicotiana attenuata)
Et_1A_008250 [endoplasmic reticulum membrane] (Eragrostis tef)
fgenesh2_kg.3__608__AT3G06060.1 [endoplasmic reticulum membrane] (Arabidopsis lyrata)
CCACVL1_01574 [endoplasmic reticulum membrane] (Corchorus capsularis)
gene-LSAT_4X32481 [endoplasmic reticulum membrane] (Lactuca sativa)
Zm00001eb251870 [endoplasmic reticulum membrane] (Zea mays ver5)
Bo9g153940 [endoplasmic reticulum membrane] (Brassica oleracea)
AVESA.00001b.r3.6Dg0000792 [endoplasmic reticulum membrane] (Avena sativa)
B456_N027600 [endoplasmic reticulum membrane] (Gossypium raimondii)
TraesCS6A02G270000 [endoplasmic reticulum membrane] (Triticum aestivum)
TCM_017113 [endoplasmic reticulum membrane] (Theobroma cacao)
Homologues of KDSR [endoplasmic reticulum membrane] (Arabidopsis lyrata)
Homologues of KDSR [endoplasmic reticulum membrane] (Arabidopsis thaliana)
Homologues of KDSR [endoplasmic reticulum membrane] (Arachis hypogaea)
Homologues of KDSR [endoplasmic reticulum membrane] (Avena sativa)
Homologues of KDSR [endoplasmic reticulum membrane] (Brassica juncea)
Homologues of KDSR [endoplasmic reticulum membrane] (Brassica napus)
Homologues of KDSR [endoplasmic reticulum membrane] (Brassica oleracea)
Homologues of KDSR [endoplasmic reticulum membrane] (Camelina sativa)
Homologues of KDSR [endoplasmic reticulum membrane] (Chenopodium quinoa)
Homologues of KDSR [endoplasmic reticulum membrane] (Corchorus capsularis)
Homologues of KDSR [endoplasmic reticulum membrane] (Corymbia citriodora)
Homologues of KDSR [endoplasmic reticulum membrane] (Digitaria exilis)
Homologues of KDSR [endoplasmic reticulum membrane] (Dioscorea rotundata)
Homologues of KDSR [endoplasmic reticulum membrane] (Echinochloa crus-galli)
Homologues of KDSR [endoplasmic reticulum membrane] (Eragrostis tef)
Homologues of KDSR [endoplasmic reticulum membrane] (Eucalyptus grandis)
Homologues of KDSR [endoplasmic reticulum membrane] (Glycine max)
Homologues of KDSR [endoplasmic reticulum membrane] (Glycine soja)
Homologues of KDSR [endoplasmic reticulum membrane] (Gossypium raimondii)
Homologues of KDSR [endoplasmic reticulum membrane] (Helianthus annuus)
Homologues of KDSR [endoplasmic reticulum membrane] (Ipomoea triloba)
Homologues of KDSR [endoplasmic reticulum membrane] (Juglans regia)
Homologues of KDSR [endoplasmic reticulum membrane] (Lactuca sativa)
Homologues of KDSR [endoplasmic reticulum membrane] (Musa acuminata)
Homologues of KDSR [endoplasmic reticulum membrane] (Olea europaea)
Homologues of KDSR [endoplasmic reticulum membrane] (Olea europaea var. sylvestris)
Homologues of KDSR [endoplasmic reticulum membrane] (Papaver somniferum)
Homologues of KDSR [endoplasmic reticulum membrane] (Prunus persica)
Homologues of KDSR [endoplasmic reticulum membrane] (Rosa chinensis)
Homologues of KDSR [endoplasmic reticulum membrane] (Selaginella moellendorffii)
Homologues of KDSR [endoplasmic reticulum membrane] (Solanum tuberosum)
Homologues of KDSR [endoplasmic reticulum membrane] (Sorghum bicolor)
Homologues of KDSR [endoplasmic reticulum membrane] (Theobroma cacao)
Homologues of KDSR [endoplasmic reticulum membrane] (Triticum aestivum)
Homologues of KDSR [endoplasmic reticulum membrane] (Triticum dicoccoides)
Homologues of KDSR [endoplasmic reticulum membrane] (Triticum spelta subsp. spelta)
Homologues of KDSR [endoplasmic reticulum membrane] (Triticum timopheevii subsp. timopheevii)
Homologues of KDSR [endoplasmic reticulum membrane] (Triticum turgidum)
Homologues of KDSR [endoplasmic reticulum membrane] (Vigna angularis)
Homologues of KDSR [endoplasmic reticulum membrane] (Zea mays)
Homologues of KDSR [endoplasmic reticulum membrane] (Zea mays ver5)
FRAEX38873_v2_000066700 [endoplasmic reticulum membrane] (Fraxinus excelsior (European ash))
Ma11_g06140 [endoplasmic reticulum membrane] (Musa acuminata)
Tritim_EIv0.3_1331550 [endoplasmic reticulum membrane] (Triticum timopheevii subsp. timopheevii)
EJB05_19654 [endoplasmic reticulum membrane] (Eragrostis curvula)
AVESA.00001b.r3.6Cg0003090 [endoplasmic reticulum membrane] (Avena sativa)
LOC114388522 [endoplasmic reticulum membrane] (Glycine soja)
Csa_3G149900 [endoplasmic reticulum membrane] (Cucumis sativus)
AET6Gv20686600 [endoplasmic reticulum membrane] (Aegilops tauschii)
HORVU.MOREX.r3.6HG0606930 [endoplasmic reticulum membrane] (Hordeum vulgare)
Potri.010G191800.v4.1 [endoplasmic reticulum membrane] (Populus trichocarpa)
SECCE6Rv1G0405700 [endoplasmic reticulum membrane] (Secale cereale)
Vitvi05g01878 [endoplasmic reticulum membrane] (Vitis vinifera)
LR48_Vigan09g210600 [endoplasmic reticulum membrane] (Vigna angularis)
Aco017246.1.path1 [endoplasmic reticulum membrane] (Ananas comosus)
GQ55_1G354600 [endoplasmic reticulum membrane] (Panicum hallii ("FIL2"))
GQ55_1G354600 [endoplasmic reticulum membrane] (Panicum hallii var. hallii ("HAL2"))
LOC114376242 [endoplasmic reticulum membrane] (Glycine soja)
MD13G0164200 [endoplasmic reticulum membrane] (Malus domestica)
PRUPE_6G197600 [endoplasmic reticulum membrane] (Prunus persica)
evm.TU.02.2635 [endoplasmic reticulum membrane] (Cannabis sativa)
CCACVL1_02231 [endoplasmic reticulum membrane] (Corchorus capsularis)
EUGRSUZ_B01115 [endoplasmic reticulum membrane] (Eucalyptus grandis)
gene-BT93_H1262 [endoplasmic reticulum membrane] (Corymbia citriodora)
DRNTG_01684 [endoplasmic reticulum membrane] (Dioscorea rotundata)
RchiOBHm_Chr6g0272851 [endoplasmic reticulum membrane] (Rosa chinensis)
Pav_sc0002011.1_g010.1.mk [endoplasmic reticulum membrane] (Prunus avium)
Csa13g022110 [endoplasmic reticulum membrane] (Camelina sativa)
Jr12_12480 [endoplasmic reticulum membrane] (Juglans regia)
BjuA10g17780S [endoplasmic reticulum membrane] (Brassica juncea)
AUR62009269 [endoplasmic reticulum membrane] (Chenopodium quinoa)
scaffold2.990 [endoplasmic reticulum membrane] (Echinochloa crus-galli)
AeUmb.TA1851.r1.4UG0014720 [endoplasmic reticulum membrane] (Aegilops umbellulata)
AMTR_s00025p00047220 [endoplasmic reticulum membrane] (Amborella trichopoda)
g13149 [endoplasmic reticulum membrane] (Arabidopsis halleri)
GLYMA_13G207200 [endoplasmic reticulum membrane] (Glycine max)
SELMODRAFT_79314 [endoplasmic reticulum membrane] (Selaginella moellendorffii)
B456_012G088500 [endoplasmic reticulum membrane] (Gossypium raimondii)
Psat1g182720 [endoplasmic reticulum membrane] (Pisum sativum)
Zm00001d051552 [endoplasmic reticulum membrane] (Zea mays)
gene-LSAT_1X50180 [endoplasmic reticulum membrane] (Lactuca sativa)
T459_13334 [endoplasmic reticulum membrane] (Capsicum annuum)
GLYMA_15G105400 [endoplasmic reticulum membrane] (Glycine max)
OE9A089410 [endoplasmic reticulum membrane] (Olea europaea)
OE9A089410 [endoplasmic reticulum membrane] (Olea europaea var. sylvestris)
OGLUM02G29820 [endoplasmic reticulum membrane] (Oryza glumaepatula)
scaffold2.989 [endoplasmic reticulum membrane] (Echinochloa crus-galli)
A4U43_C04F10550 [endoplasmic reticulum membrane] (Asparagus officinalis)
Tritim_EIv0.3_1223250 [endoplasmic reticulum membrane] (Triticum timopheevii subsp. timopheevii)
AVESA.00001b.r3.6Ag0001105 [endoplasmic reticulum membrane] (Avena sativa)
C5167_005606 [endoplasmic reticulum membrane] (Papaver somniferum)
PGSC0003DMG402004220 [endoplasmic reticulum membrane] (Solanum tuberosum)
C5167_022943 [endoplasmic reticulum membrane] (Papaver somniferum)
Ma08_g15830 [endoplasmic reticulum membrane] (Musa acuminata)
Manes.08G075500.v8.1 [endoplasmic reticulum membrane] (Manihot esculenta)
arahy.Tifrunner.gnm2.ann2.Ah04g041200 [endoplasmic reticulum membrane] (Arachis hypogaea)
OE9A037872 [endoplasmic reticulum membrane] (Olea europaea)
OE9A037872 [endoplasmic reticulum membrane] (Olea europaea var. sylvestris)
MELO3C006553.2 [endoplasmic reticulum membrane] (Cucumis melo)
NC1G0135340 [endoplasmic reticulum membrane] (Nymphaea colorata)
fgenesh1_pm.C_scaffold_6001539 [endoplasmic reticulum membrane] (Arabidopsis lyrata)
B456_009G240900 [endoplasmic reticulum membrane] (Gossypium raimondii)
RchiOBHm_Chr6g0272831 [endoplasmic reticulum membrane] (Rosa chinensis)
ORUFI02G30810 [endoplasmic reticulum membrane] (Oryza rufipogon)
KN538719.1_FG074 [endoplasmic reticulum membrane] (Oryza longistaminata)
SELMODRAFT_78109 [endoplasmic reticulum membrane] (Selaginella moellendorffii)
TraesCS6B02G297300 [endoplasmic reticulum membrane] (Triticum aestivum)
Aradu.NP2NU [endoplasmic reticulum membrane] (Arachis duranensis)
LR48_Vigan02g008900 [endoplasmic reticulum membrane] (Vigna angularis)
Vradi10g08280 [endoplasmic reticulum membrane] (Vigna radiata)
gene-BT93_H1263 [endoplasmic reticulum membrane] (Corymbia citriodora)
DCAR_027180 [endoplasmic reticulum membrane] (Daucus carota)
gene8180 [endoplasmic reticulum membrane] (Medicago truncatula)
BGIOSGA008878 [endoplasmic reticulum membrane] (Oryza sativa Indica Group)
LPERR02G23760 [endoplasmic reticulum membrane] (Leersia perrieri)
Vigun06g164400.v1.2 [endoplasmic reticulum membrane] (Vigna unguiculata)
OB02G36370 [endoplasmic reticulum membrane] (Oryza brachyantha)
OPUNC02G26800 [endoplasmic reticulum membrane] (Oryza punctata)
Tp57577_TGAC_v2_gene7640 [endoplasmic reticulum membrane] (Trifolium pratense)
Dexi1A01G0024350 [endoplasmic reticulum membrane] (Digitaria exilis)
Csa08g011830 [endoplasmic reticulum membrane] (Camelina sativa)
Solyc06g054330.3 [endoplasmic reticulum membrane] (Solanum lycopersicum)
Et_1B_013074 [endoplasmic reticulum membrane] (Eragrostis tef)
RchiOBHm_Chr6g0272861 [endoplasmic reticulum membrane] (Rosa chinensis)
Ccrd_021846 [endoplasmic reticulum membrane] (Cynara cardunculus var. scolymus)
C.cajan_05320 [endoplasmic reticulum membrane] (Cajanus cajan)
Zm00001d017748 [endoplasmic reticulum membrane] (Zea mays)
GSBRNA2T00038508001 [endoplasmic reticulum membrane] (Brassica napus)
SEVIR_1G292400v2 [endoplasmic reticulum membrane] (Setaria viridis)
LR48_Vigan741s000700 [endoplasmic reticulum membrane] (Vigna angularis)
RchiOBHm_Chr6g0272751 [endoplasmic reticulum membrane] (Rosa chinensis)
SORBI_3004G269700 [endoplasmic reticulum membrane] (Sorghum bicolor)
KYUSg_chr6.11676 [endoplasmic reticulum membrane] (Lolium perenne)
GSBRNA2T00072015001 [endoplasmic reticulum membrane] (Brassica napus)
Mp1g04350 [endoplasmic reticulum membrane] (Marchantia polymorpha)
arahy.Tifrunner.gnm2.ann2.Ah14g056600 [endoplasmic reticulum membrane] (Arachis hypogaea)
gene-LATHSAT_LOCUS877 [endoplasmic reticulum membrane] (Lathyrus sativus)
Dexi1B01G0023400 [endoplasmic reticulum membrane] (Digitaria exilis)
BjuA05g35610S [endoplasmic reticulum membrane] (Brassica juncea)
SORBI_3004G337066 [endoplasmic reticulum membrane] (Sorghum bicolor)
AT3G06060 [endoplasmic reticulum membrane] (Arabidopsis thaliana)
CICLE_v10005413mg [endoplasmic reticulum membrane] (Citrus clementina)
EUGRSUZ_B01113 [endoplasmic reticulum membrane] (Eucalyptus grandis)
Pp3c22_14290 [endoplasmic reticulum membrane] (Physcomitrella patens)
C5167_020796 [endoplasmic reticulum membrane] (Papaver somniferum)
gene-BT93_H1264 [endoplasmic reticulum membrane] (Corymbia citriodora)
itb04g20460 [endoplasmic reticulum membrane] (Ipomoea triloba)
CEY00_Acc04274 [endoplasmic reticulum membrane] (Actinidia chinensis)
Jr07_20340 [endoplasmic reticulum membrane] (Juglans regia)