homogentisate 1,2-dioxygenase

Stable Identifier
R-OSA-1127734
Type
Protein [EntityWithAccessionedSequence]
Species
Oryza sativa
Synonyms
phys-ent-participant87706
Locations in the PathwayBrowser
Expand all
Summation

Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the reaction of homogentisate and molecular oxygen to form 4-maleylacetoacetate. HGD is a homohexamer, with each monomer binding one Fe(2+) ion as a catalytic cofactor (Titus et al., 2000; Veldhuizen et al., 2005). HGD activity is defective in alkaptonuria patients who excrete excess homogentisate and its oxidized form alkapton in the urine, with further metabolic complications (MIM:203500; Fernandez-Canon et al. 1996; reviewed in Zatkova et al., 2020).

External Reference Information
External Reference
UniProt:Q5VRH4 Os06g0103300
Gene Names
Os06g0103300, LOC_Os06g01360, OsJ_19811, HGO, OSJNBa0075G19.26
Chain
chain:1-470
Inferred To
EJB05_46609 [cytosol] (Eragrostis curvula)
OfLcomp10608_c0_seq1 [cytosol] (Oryza officinalis)
Tritim_EIv0.3_1371200 [cytosol] (Triticum timopheevii subsp. timopheevii)
Vitvi19g00150 [cytosol] (Vitis vinifera)
CHLRE_02g091200v5 [cytosol] (Chlamydomonas reinhardtii)
PITA_000022525-RA [cytosol] (Pinus taeda)
Mp5g00020 [cytosol] (Marchantia polymorpha)
Migut.M00760.1 [cytosol] (Erythranthe guttata)
A02p016630.1_BraROA [cytosol] (Brassica rapa)
AeUmb.TA1851.r1.7UG0045940 [cytosol] (Aegilops umbellulata)
scaffold44.13 [cytosol] (Echinochloa crus-galli)
Pav_sc0003492.1_g410.1.mk [cytosol] (Prunus avium)
OE9A078624 [cytosol] (Olea europaea)
OE9A078624 [cytosol] (Olea europaea var. sylvestris)
KN539498.1_FG004 [cytosol] (Oryza longistaminata)
TRITD4Av1G261980 [cytosol] (Triticum turgidum)
ORGLA06G0001400 [cytosol] (Oryza glaberrima)
Potri.001G374100.v4.1 [cytosol] (Populus trichocarpa)
Sspon.08G0013010-2B [cytosol] (Saccharum spontaneum)
GrLcomp108716_c0_seq2 [cytosol] (Oryza meyeriana var. granulata)
LR48_Vigan08g187000 [cytosol] (Vigna angularis)
Cla002425 [cytosol] (Citrullus lanatus)
GSBRNA2T00078952001 [cytosol] (Brassica napus)
QL08p027671 [cytosol] (Quercus lobata)
Tp57577_TGAC_v2_gene22540 [cytosol] (Trifolium pratense)
TraesCS4A02G495000 [cytosol] (Triticum aestivum)
HanXRQr2_Chr03g0115031 [cytosol] (Helianthus annuus)
JcCB0140211.10 [cytosol] (Jatropha curcas)
Csa11g086030 [cytosol] (Camelina sativa)
GLYMA_06G234200 [cytosol] (Glycine max)
BGIOSGA022113 [cytosol] (Oryza sativa Indica Group)
MiLcomp127658_c0_seq2 [cytosol] (Oryza minuta)
LOC114416810 [cytosol] (Glycine soja)
SETIT_006403mg [cytosol] (Setaria italica)
AT5G54080 [cytosol] (Arabidopsis thaliana)
FRAEX38873_v2_000007780 [cytosol] (Fraxinus excelsior (European ash))
OPUNC06G00120 [cytosol] (Oryza punctata)
Manes.03G103900.v8.1 [cytosol] (Manihot esculenta)
Vfaba.Hedin2.R1.4g012960 [cytosol] (Vicia faba var. faba)
evm.TU.09.101 [cytosol] (Cannabis sativa)
AVESA.00001b.r3.7Dg0003596 [cytosol] (Avena sativa)
Aradu.NC6JU [cytosol] (Arachis duranensis)
orange1.1g011934m [cytosol] (Citrus sinensis)
BVRB_4g086200 [cytosol] (Beta vulgaris)
GrLcomp109162_c0_seq2 [cytosol] (Oryza meyeriana var. granulata)
Zm00001eb379510 [cytosol] (Zea mays ver5)
GQ55_4G370200 [cytosol] (Panicum hallii ("FIL2"))
GQ55_4G370200 [cytosol] (Panicum hallii var. hallii ("HAL2"))
AMTR_s00064p00100410 [cytosol] (Amborella trichopoda)
FCD_00012239 [cytosol] (Ficus carica)
arahy.Tifrunner.gnm2.ann2.Ah03g224100 [cytosol] (Arachis hypogaea)
g09442 [cytosol] (Arabidopsis halleri)
BjuA02g29950S [cytosol] (Brassica juncea)
C.cajan_14661 [cytosol] (Cajanus cajan)
LOC114380340 [cytosol] (Glycine soja)
gene-CFP56_14997 [cytosol] (Quercus suber)
Csa_4G088750 [cytosol] (Cucumis sativus)
NC9G0147350 [cytosol] (Nymphaea colorata)
Tritim_EIv0.3_1498620 [cytosol] (Triticum timopheevii subsp. timopheevii)
GrLcomp108716_c0_seq1 [cytosol] (Oryza meyeriana var. granulata)
GrLcomp109162_c0_seq1 [cytosol] (Oryza meyeriana var. granulata)
gene-BT93_C0807 [cytosol] (Corymbia citriodora)
CICLE_v10008509mg [cytosol] (Citrus clementina)
AVESA.00001b.r3.7Ag0000542 [cytosol] (Avena sativa)
Ma10_g02490 [cytosol] (Musa acuminata)
OMERI06G00130 [cytosol] (Oryza meridionalis)
arahy.Tifrunner.gnm2.ann2.Ah13g250500 [cytosol] (Arachis hypogaea)
GrLcomp108716_c0_seq4 [cytosol] (Oryza meyeriana var. granulata)
DCAR_028453 [cytosol] (Daucus carota)
g35336 [cytosol] (Salvia hispanica)
EUGRSUZ_F01184 [cytosol] (Eucalyptus grandis)
PDK_30s765421g002 [cytosol] (Phoenix dactylifera)
Carubv10026329m [cytosol] (Capsella rubella)
orange1.1g011768m [cytosol] (Citrus sinensis)
SELMODRAFT_267178 [cytosol] (Selaginella moellendorffii)
itb06g05210 [cytosol] (Ipomoea triloba)
Ca_16233 [cytosol] (Cicer arietinum)
TraesCS7D02G004100 [cytosol] (Triticum aestivum)
GSBRNA2T00073644001 [cytosol] (Brassica napus)
Pp3c16_940 [cytosol] (Physcomitrella patens)
C5167_039577 [cytosol] (Papaver somniferum)
CHC_T00008952001 [cytosol] (Chondrus crispus)
DRNTG_32642 [cytosol] (Dioscorea rotundata)
Ccrd_019526 [cytosol] (Cynara cardunculus var. scolymus)
TraesTSP7D01G017700 [cytosol] (Triticum spelta subsp. spelta)
MiLcomp127658_c0_seq1 [cytosol] (Oryza minuta)
OB06G10210 [cytosol] (Oryza brachyantha)
NNU_15740-RA [cytosol] (Nelumbo nucifera)
SECCE4Rv1G0284400 [cytosol] (Secale cereale)
T459_23803 [cytosol] (Capsicum annuum)
EUGRSUZ_F01185 [cytosol] (Eucalyptus grandis)
GrLcomp109162_c0_seq6 [cytosol] (Oryza meyeriana var. granulata)
GLYMA_12G158600 [cytosol] (Glycine max)
PHAVU_011G148800g [cytosol] (Phaseolus vulgaris)
BRADI_1g52291v3 [cytosol] (Brachypodium distachyon)
GSBRNA2T00086219001 [cytosol] (Brassica napus)
LPERR06G00150 [cytosol] (Leersia perrieri)
ONIVA06G00150 [cytosol] (Oryza nivara)
PGSC0003DMG400015330 [cytosol] (Solanum tuberosum)
OGLUM06G00100 [cytosol] (Oryza glumaepatula)
Zjn_sc00184.1.g00280.1.sm.mkhc [cytosol] (Zoysia japonica)
EJB05_46628 [cytosol] (Eragrostis curvula)
TRIDC4AG071230 [cytosol] (Triticum dicoccoides)
Et_2B_019525 [cytosol] (Eragrostis tef)
Jr09_13740 [cytosol] (Juglans regia)
orange1.1g019943m [cytosol] (Citrus sinensis)
CCACVL1_16425 [cytosol] (Corchorus capsularis)
Aco000300.1.path1 [cytosol] (Ananas comosus)
Vradi02g02500 [cytosol] (Vigna radiata)
scaffold422.13 [cytosol] (Echinochloa crus-galli)
ORUFI06G00160 [cytosol] (Oryza rufipogon)
A4A49_26656 [cytosol] (Nicotiana attenuata)
GSBRNA2T00041448001 [cytosol] (Brassica napus)
Et_2A_015251 [cytosol] (Eragrostis tef)
gene-LATHSAT_LOCUS14959 [cytosol] (Lathyrus sativus)
Vigun11g066900.v1.2 [cytosol] (Vigna unguiculata)
AET7Gv20009100 [cytosol] (Aegilops tauschii)
scaffold_801917.1 [cytosol] (Arabidopsis lyrata)
Araip.CQ2I9 [cytosol] (Arachis ipaensis)
Psat4g138640 [cytosol] (Pisum sativum)
PRUPE_4G172100 [cytosol] (Prunus persica)
Solyc12g014100.2 [cytosol] (Solanum lycopersicum)
B456_002G065000 [cytosol] (Gossypium raimondii)
GLYMA_06G233800 [cytosol] (Glycine max)
PK01991.1 [cytosol] (Cannabis sativa subsp. indica)
CEY00_Acc26434 [cytosol] (Actinidia chinensis)
KYUSg_chr7.41108 [cytosol] (Lolium perenne)
MA_44565g0010 [cytosol] (Picea abies)
Csa02g051740 [cytosol] (Camelina sativa)
MD03G0195700 [cytosol] (Malus domestica)
TraesTSP4A01G532500 [cytosol] (Triticum spelta subsp. spelta)
A4U43_C06F10750 [cytosol] (Asparagus officinalis)
TRITD7Av1G000240 [cytosol] (Triticum turgidum)
MELO3C016089.2 [cytosol] (Cucumis melo)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Arachis hypogaea)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Avena sativa)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Brassica napus)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Camelina sativa)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Citrus sinensis)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Echinochloa crus-galli)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Eragrostis curvula)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Eragrostis tef)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Eucalyptus grandis)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Glycine max)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Glycine soja)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Ipomoea triloba)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Juglans regia)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Oryza australiensis)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Oryza meyeriana var. granulata)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Oryza minuta)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Oryza officinalis)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Papaver somniferum)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Saccharum spontaneum)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Selaginella moellendorffii)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Triticum aestivum)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Triticum dicoccoides)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Triticum spelta subsp. spelta)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Triticum timopheevii subsp. timopheevii)
Homologues of homogentisate 1,2-dioxygenase [cytosol] (Triticum turgidum)
SIN_1022568 [cytosol] (Sesamum indicum)
MiLcomp127658_c0_seq3 [cytosol] (Oryza minuta)
TRIDC7AG000600 [cytosol] (Triticum dicoccoides)
HORVU.MOREX.r3.7HG0634790 [cytosol] (Hordeum vulgare)
Jr02_21380 [cytosol] (Juglans regia)
Gasu_31150 [cytosol] (Galdieria sulphuraria)
HUMLU_hap_000210F_004.g1.t1 [cytosol] (Humulus lupulus)
EVM0026917 [cytosol] (Pistacia vera)
gene47177 [cytosol] (Medicago truncatula)
GrLcomp109162_c0_seq5 [cytosol] (Oryza meyeriana var. granulata)
OfLcomp10608_c0_seq2 [cytosol] (Oryza officinalis)
gene-LSAT_9X98620 [cytosol] (Lactuca sativa)
TCM_031685 [cytosol] (Theobroma cacao)
itb06g05190 [cytosol] (Ipomoea triloba)
AUR62019513 [cytosol] (Chenopodium quinoa)
TuG1812G0700000032.01 [cytosol] (Triticum urartu)
OBART06G00140 [cytosol] (Oryza barthii)
Zm00001d045610 [cytosol] (Zea mays)
AuLcomp18868_c0_seq1 [cytosol] (Oryza australiensis)
Sspon.08G0013010-1A [cytosol] (Saccharum spontaneum)
CMI106C [cytosol] (Cyanidioschyzon merolae)
C5167_008953 [cytosol] (Papaver somniferum)
AVESA.00001b.r3.5Cg0003404 [cytosol] (Avena sativa)
Csa18g025330 [cytosol] (Camelina sativa)
SORBI_3010G001600 [cytosol] (Sorghum bicolor)
GrLcomp108716_c0_seq3 [cytosol] (Oryza meyeriana var. granulata)
AuLcomp18861_c0_seq1 [cytosol] (Oryza australiensis)
TraesCS7A02G003600 [cytosol] (Triticum aestivum)
mrna27194.1-v1.0-hybrid [cytosol] (Fragaria vesca)
RchiOBHm_Chr5g0031821 [cytosol] (Rosa chinensis)
TanjilG_15194 [cytosol] (Lupinus angustifolius)
SELMODRAFT_151052 [cytosol] (Selaginella moellendorffii)
SEVIR_4G002300v2 [cytosol] (Setaria viridis)
GSCOC_T00021307001 [cytosol] (Coffea canephora)
Cross References
UniProt