fumarylacetoacetase

Stable Identifier
R-OSA-1121719
Type
Set [DefinedSet]
Species
Oryza sativa
Synonyms
fumarylacetoacetate hydrolase family protein//catalytic (LOC_OS03G30800.1)
Locations in the PathwayBrowser
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Summation

This is the final step of tyrosine degradation. Fumarylacetoacetase catalyzes the hydrolysis of 4-fumarylacetoacetate (4FAA) to form fumarate and acetoacetate. The enzyme is a homodimer, with each monomer binding one Ca(2+) and one Mg(2+) ion as catalytic cofactors, as shown in a mouse structure (Hsiang et al., 1972; Labelle et al. 1993; Bateman et al., 2001). FAH deficiency leads to tyrosinemia type I (TYRSN1, MIM:276700) characterized by 4FAA accumulation with severe metabolic effects (reviewed in Pitkänen et al., 2000; Scott, 2006).

Participants
members
Inferred To
CBR_g26355 [mitochondrion] (Chara braunii)
Aradu.M5CVM [mitochondrion] (Arachis duranensis)
Homologues of fumarylacetoacetase [mitochondrion] (Arachis hypogaea)
Homologues of fumarylacetoacetase [mitochondrion] (Asparagus officinalis)
Homologues of fumarylacetoacetase [mitochondrion] (Avena sativa)
Homologues of fumarylacetoacetase [mitochondrion] (Brassica juncea)
Homologues of fumarylacetoacetase [mitochondrion] (Camelina sativa)
Homologues of fumarylacetoacetase [mitochondrion] (Citrus sinensis)
Homologues of fumarylacetoacetase [mitochondrion] (Digitaria exilis)
Homologues of fumarylacetoacetase [mitochondrion] (Echinochloa crus-galli)
Homologues of fumarylacetoacetase [mitochondrion] (Eragrostis tef)
Homologues of fumarylacetoacetase [mitochondrion] (Glycine max)
Homologues of fumarylacetoacetase [mitochondrion] (Glycine soja)
Homologues of fumarylacetoacetase [mitochondrion] (Humulus lupulus)
Homologues of fumarylacetoacetase [mitochondrion] (Humulus lupulus var. lupulus)
Homologues of fumarylacetoacetase [mitochondrion] (Oryza australiensis)
Homologues of fumarylacetoacetase [mitochondrion] (Oryza meyeriana var. granulata)
Homologues of fumarylacetoacetase [mitochondrion] (Oryza officinalis)
Homologues of fumarylacetoacetase [mitochondrion] (Selaginella moellendorffii)
Homologues of fumarylacetoacetase [mitochondrion] (Solanum tuberosum)
Homologues of fumarylacetoacetase [mitochondrion] (Triticum aestivum)
Homologues of fumarylacetoacetase [mitochondrion] (Triticum dicoccoides)
Homologues of fumarylacetoacetase [mitochondrion] (Triticum spelta subsp. spelta)
Homologues of fumarylacetoacetase [mitochondrion] (Triticum timopheevii subsp. timopheevii)
Homologues of fumarylacetoacetase [mitochondrion] (Triticum turgidum)
Homologues of fumarylacetoacetase [mitochondrion] (Zea mays ver5)
Homologues of fumarylacetoacetase [mitochondrion] (Zoysia japonica)
GQ55_1G071700 [mitochondrion] (Panicum hallii ("FIL2"))
GQ55_1G071700 [mitochondrion] (Panicum hallii var. hallii ("HAL2"))
Pav_sc0001084.1_g360.1.mk [mitochondrion] (Prunus avium)
MD10G0282500 [mitochondrion] (Malus domestica)
SORBI_3004G080100 [mitochondrion] (Sorghum bicolor)
CHLRE_17g732802v5 [mitochondrion] (Chlamydomonas reinhardtii)
A0A1R3H374 [mitochondrion] (Corchorus olitorius)
LR48_Vigan09g196900 [mitochondrion] (Vigna angularis)
CCACVL1_15306 [mitochondrion] (Corchorus capsularis)
Zm00001d053663 [mitochondrion] (Zea mays)
SEVIR_1G048700v2 [mitochondrion] (Setaria viridis)
BAA17682 [mitochondrion] (Synechocystis sp. PCC 6803)
PITA_000011491-RA [mitochondrion] (Pinus taeda)
PK00668.1 [mitochondrion] (Cannabis sativa subsp. indica)
fumarylacetoacetase [mitochondrion] (Actinidia chinensis)
fumarylacetoacetase [mitochondrion] (Aegilops tauschii)
fumarylacetoacetase [mitochondrion] (Aegilops umbellulata)
fumarylacetoacetase [mitochondrion] (Amborella trichopoda)
fumarylacetoacetase [mitochondrion] (Ananas comosus)
fumarylacetoacetase [mitochondrion] (Arabidopsis halleri)
fumarylacetoacetase [mitochondrion] (Arabidopsis lyrata)
fumarylacetoacetase [mitochondrion] (Arabidopsis thaliana)
fumarylacetoacetase [mitochondrion] (Arachis ipaensis)
fumarylacetoacetase [mitochondrion] (Beta vulgaris)
fumarylacetoacetase [mitochondrion] (Brachypodium distachyon)
fumarylacetoacetase [mitochondrion] (Brassica napus)
fumarylacetoacetase [mitochondrion] (Brassica oleracea)
fumarylacetoacetase [mitochondrion] (Brassica rapa)
fumarylacetoacetase [mitochondrion] (Cajanus cajan)
fumarylacetoacetase [mitochondrion] (Cannabis sativa)
fumarylacetoacetase [mitochondrion] (Capsella rubella)
fumarylacetoacetase [mitochondrion] (Capsicum annuum)
fumarylacetoacetase [mitochondrion] (Chenopodium quinoa)
fumarylacetoacetase [mitochondrion] (Chondrus crispus)
fumarylacetoacetase [mitochondrion] (Cicer arietinum)
fumarylacetoacetase [mitochondrion] (Citrullus lanatus)
fumarylacetoacetase [mitochondrion] (Citrus clementina)
fumarylacetoacetase [mitochondrion] (Coffea canephora)
fumarylacetoacetase [mitochondrion] (Corymbia citriodora)
fumarylacetoacetase [mitochondrion] (Cucumis melo)
fumarylacetoacetase [mitochondrion] (Cucumis sativus)
fumarylacetoacetase [mitochondrion] (Cyanidioschyzon merolae)
fumarylacetoacetase [mitochondrion] (Cynara cardunculus var. scolymus)
fumarylacetoacetase [mitochondrion] (Daucus carota)
fumarylacetoacetase [mitochondrion] (Dioscorea rotundata)
fumarylacetoacetase [mitochondrion] (Erythranthe guttata)
fumarylacetoacetase [mitochondrion] (Eucalyptus grandis)
fumarylacetoacetase [mitochondrion] (Ficus carica)
fumarylacetoacetase [mitochondrion] (Fragaria vesca)
fumarylacetoacetase [mitochondrion] (Fraxinus excelsior (European ash))
fumarylacetoacetase [mitochondrion] (Galdieria sulphuraria)
fumarylacetoacetase [mitochondrion] (Gossypium raimondii)
fumarylacetoacetase [mitochondrion] (Helianthus annuus)
fumarylacetoacetase [mitochondrion] (Hordeum vulgare)
fumarylacetoacetase [mitochondrion] (Ipomoea triloba)
fumarylacetoacetase [mitochondrion] (Jatropha curcas)
fumarylacetoacetase [mitochondrion] (Juglans regia)
fumarylacetoacetase [mitochondrion] (Lactuca sativa)
fumarylacetoacetase [mitochondrion] (Lathyrus sativus)
fumarylacetoacetase [mitochondrion] (Leersia perrieri)
fumarylacetoacetase [mitochondrion] (Lolium perenne)
fumarylacetoacetase [mitochondrion] (Lupinus angustifolius)
fumarylacetoacetase [mitochondrion] (Manihot esculenta)
fumarylacetoacetase [mitochondrion] (Marchantia polymorpha)
fumarylacetoacetase [mitochondrion] (Medicago truncatula)
fumarylacetoacetase [mitochondrion] (Musa acuminata)
fumarylacetoacetase [mitochondrion] (Nelumbo nucifera)
fumarylacetoacetase [mitochondrion] (Nicotiana attenuata)
fumarylacetoacetase [mitochondrion] (Nymphaea colorata)
fumarylacetoacetase [mitochondrion] (Olea europaea)
fumarylacetoacetase [mitochondrion] (Olea europaea var. sylvestris)
fumarylacetoacetase [mitochondrion] (Oryza barthii)
fumarylacetoacetase [mitochondrion] (Oryza brachyantha)
fumarylacetoacetase [mitochondrion] (Oryza glaberrima)
fumarylacetoacetase [mitochondrion] (Oryza glumaepatula)
fumarylacetoacetase [mitochondrion] (Oryza meridionalis)
fumarylacetoacetase [mitochondrion] (Oryza minuta)
fumarylacetoacetase [mitochondrion] (Oryza nivara)
fumarylacetoacetase [mitochondrion] (Oryza punctata)
fumarylacetoacetase [mitochondrion] (Oryza rufipogon)
fumarylacetoacetase [mitochondrion] (Oryza sativa Indica Group)
fumarylacetoacetase [mitochondrion] (Papaver somniferum)
fumarylacetoacetase [mitochondrion] (Phaseolus vulgaris)
fumarylacetoacetase [mitochondrion] (Phoenix dactylifera)
fumarylacetoacetase [mitochondrion] (Phyllostachys edulis)
fumarylacetoacetase [mitochondrion] (Physcomitrella patens)
fumarylacetoacetase [mitochondrion] (Pistacia vera)
fumarylacetoacetase [mitochondrion] (Pisum sativum)
fumarylacetoacetase [mitochondrion] (Populus trichocarpa)
fumarylacetoacetase [mitochondrion] (Prunus persica)
fumarylacetoacetase [mitochondrion] (Quercus lobata)
fumarylacetoacetase [mitochondrion] (Quercus suber)
fumarylacetoacetase [mitochondrion] (Rosa chinensis)
fumarylacetoacetase [mitochondrion] (Salvia hispanica)
fumarylacetoacetase [mitochondrion] (Secale cereale)
fumarylacetoacetase [mitochondrion] (Sesamum indicum)
fumarylacetoacetase [mitochondrion] (Solanum lycopersicum)
fumarylacetoacetase [mitochondrion] (Theobroma cacao)
fumarylacetoacetase [mitochondrion] (Trifolium pratense)
fumarylacetoacetase [mitochondrion] (Triticum urartu)
fumarylacetoacetase [mitochondrion] (Vicia faba var. faba)
fumarylacetoacetase [mitochondrion] (Vigna radiata)
fumarylacetoacetase [mitochondrion] (Vigna unguiculata)
fumarylacetoacetase [mitochondrion] (Vitis vinifera)
Os02t0196800-01 [mitochondrion] (Oryza sativa aus subgroup)
EJB05_24703 [mitochondrion] (Eragrostis curvula)
KN538806.1_FG017 [mitochondrion] (Oryza longistaminata)
SETIT_017294mg [mitochondrion] (Setaria italica)