Proline degradation

Stable Identifier
R-OSA-1119337
Type
Pathway
Species
Oryza sativa
Compartment
mitochondrial matrix
Synonyms
proline utilization, pathway99539
Locations in the PathwayBrowser
Expand all
Summation

High concentrations of proline in the cell increase reactive oxygen species (ROS) formation in the mitochondrion. Proline catabolism is repressed under osmotic stress but once the stress is withdrawn, proline is oxidized to ?1-pyrroline-5-carboxylic acid (P5C) by proline dehydrogenase (PDH; EC 1.5.99.8), also known as proline oxidase, the first enzyme in the proline degradation pathway. P5C is then converted back to glutamate by the enzyme P5C dehydrogenase (P5CDH; 1.5.1.12) (Forlani et al., 1997). Thus, both PDH and P5CDH form two important enzymes in the degradation of proline to glutamate in higher organisms. During the recovery from stress, this short catabolic pathway provides energy, reducing power and precursors for nucleotide synthesis to allow the resumption of cell division (Hare and Cress, 1997).

Data source: RiceCyc

Literature References
PubMed ID Title Journal Year
25150410 RNAi-directed downregulation of betaine aldehyde dehydrogenase 1 (OsBADH1) results in decreased stress tolerance and increased oxidative markers without affecting glycine betaine biosynthesis in rice (Oryza sativa) Plant Mol. Biol. 2014
9106509 Characterization of the gene for delta1-pyrroline-5-carboxylate synthetase and correlation between the expression of the gene and salt tolerance in Oryza sativa L Plant Mol. Biol. 1997
25599829 Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology Plant Biotechnol. J. 2015
11027709 Expression of a gene encoding mitochondrial aldehyde dehydrogenase in rice increases under submerged conditions Plant Physiol. 2000
26347750 Connecting proline metabolism and signaling pathways in plant senescence Front Plant Sci 2015
12832071 Induction of mitochondrial aldehyde dehydrogenase by submergence facilitates oxidation of acetaldehyde during re-aeration in rice FEBS Lett. 2003
12609740 Organ-specific expressions and chromosomal locations of two mitochondrial aldehyde dehydrogenase genes from rice (Oryza sativa L.), ALDH2a and ALDH2b Gene 2003
26217357 Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens Front Plant Sci 2015
24001856 Comparative quantitative analysis of headspace volatiles and their association with BADH2 marker in non-basmati scented, basmati and non-scented rice (Oryza sativa L.) cultivars of India Food Chem 2014
26300893 Functional characterization and expression analysis of rice ?(1)-pyrroline-5-carboxylate dehydrogenase provide new insight into the regulation of proline and arginine catabolism Front Plant Sci 2015
26258482 Resequencing Reveals Different Domestication Rate for BADH1 and BADH2 in Rice (Oryza sativa) PLoS ONE 2015
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
proline catabolic process (0006562)
Orthologous Events
Proline degradation (Actinidia chinensis)
Proline degradation (Aegilops tauschii)
Proline degradation (Aegilops umbellulata)
Proline degradation (Amborella trichopoda)
Proline degradation (Ananas comosus)
Proline degradation (Arabidopsis halleri)
Proline degradation (Arabidopsis lyrata)
Proline degradation (Arabidopsis thaliana)
Proline degradation (Arachis duranensis)
Proline degradation (Arachis hypogaea)
Proline degradation (Arachis ipaensis)
Proline degradation (Asparagus officinalis)
Proline degradation (Avena sativa)
Proline degradation (Beta vulgaris)
Proline degradation (Brachypodium distachyon)
Proline degradation (Brassica juncea)
Proline degradation (Brassica napus)
Proline degradation (Brassica oleracea)
Proline degradation (Brassica rapa)
Proline degradation (Cajanus cajan)
Proline degradation (Camelina sativa)
Proline degradation (Cannabis sativa)
Proline degradation (Cannabis sativa subsp. indica)
Proline degradation (Capsella rubella)
Proline degradation (Capsicum annuum)
Proline degradation (Chara braunii)
Proline degradation (Chenopodium quinoa)
Proline degradation (Chlamydomonas reinhardtii)
Proline degradation (Cicer arietinum)
Proline degradation (Citrullus lanatus)
Proline degradation (Citrus clementina)
Proline degradation (Citrus sinensis)
Proline degradation (Coffea canephora)
Proline degradation (Corchorus capsularis)
Proline degradation (Corchorus olitorius)
Proline degradation (Corymbia citriodora)
Proline degradation (Cucumis melo)
Proline degradation (Cucumis sativus)
Proline degradation (Cynara cardunculus var. scolymus)
Proline degradation (Daucus carota)
Proline degradation (Digitaria exilis)
Proline degradation (Dioscorea rotundata)
Proline degradation (Echinochloa crus-galli)
Proline degradation (Eragrostis curvula)
Proline degradation (Eragrostis tef)
Proline degradation (Erythranthe guttata)
Proline degradation (Eucalyptus grandis)
Proline degradation (Ficus carica)
Proline degradation (Fragaria vesca)
Proline degradation (Fraxinus excelsior (European ash))
Proline degradation (Galdieria sulphuraria)
Proline degradation (Glycine max)
Proline degradation (Glycine soja)
Proline degradation (Gossypium raimondii)
Proline degradation (Helianthus annuus)
Proline degradation (Hordeum vulgare)
Proline degradation (Humulus lupulus)
Proline degradation (Humulus lupulus var. lupulus)
Proline degradation (Ipomoea triloba)
Proline degradation (Jatropha curcas)
Proline degradation (Juglans regia)
Proline degradation (Lactuca sativa)
Proline degradation (Lathyrus sativus)
Proline degradation (Leersia perrieri)
Proline degradation (Lolium perenne)
Proline degradation (Lupinus angustifolius)
Proline degradation (Malus domestica)
Proline degradation (Manihot esculenta)
Proline degradation (Marchantia polymorpha)
Proline degradation (Medicago truncatula)
Proline degradation (Musa acuminata)
Proline degradation (Nelumbo nucifera)
Proline degradation (Nicotiana attenuata)
Proline degradation (Nymphaea colorata)
Proline degradation (Olea europaea)
Proline degradation (Olea europaea var. sylvestris)
Proline degradation (Oryza australiensis)
Proline degradation (Oryza barthii)
Proline degradation (Oryza brachyantha)
Proline degradation (Oryza glaberrima)
Proline degradation (Oryza glumaepatula)
Proline degradation (Oryza longistaminata)
Proline degradation (Oryza meridionalis)
Proline degradation (Oryza meyeriana var. granulata)
Proline degradation (Oryza minuta)
Proline degradation (Oryza nivara)
Proline degradation (Oryza officinalis)
Proline degradation (Oryza punctata)
Proline degradation (Oryza rufipogon)
Proline degradation (Oryza sativa Indica Group)
Proline degradation (Oryza sativa aus subgroup)
Proline degradation (Ostreococcus lucimarinus)
Proline degradation (Panicum hallii ("FIL2"))
Proline degradation (Panicum hallii var. hallii ("HAL2"))
Proline degradation (Papaver somniferum)
Proline degradation (Phaseolus vulgaris)
Proline degradation (Phoenix dactylifera)
Proline degradation (Phyllostachys edulis)
Proline degradation (Physcomitrella patens)
Proline degradation (Picea abies)
Proline degradation (Pinus taeda)
Proline degradation (Pistacia vera)
Proline degradation (Pisum sativum)
Proline degradation (Populus trichocarpa)
Proline degradation (Prunus avium)
Proline degradation (Prunus persica)
Proline degradation (Quercus lobata)
Proline degradation (Quercus suber)
Proline degradation (Rosa chinensis)
Proline degradation (Saccharum spontaneum)
Proline degradation (Salvia hispanica)
Proline degradation (Secale cereale)
Proline degradation (Selaginella moellendorffii)
Proline degradation (Sesamum indicum)
Proline degradation (Setaria italica)
Proline degradation (Setaria viridis)
Proline degradation (Solanum lycopersicum)
Proline degradation (Solanum tuberosum)
Proline degradation (Sorghum bicolor)
Proline degradation (Theobroma cacao)
Proline degradation (Trifolium pratense)
Proline degradation (Triticum aestivum)
Proline degradation (Triticum dicoccoides)
Proline degradation (Triticum spelta subsp. spelta)
Proline degradation (Triticum timopheevii subsp. timopheevii)
Proline degradation (Triticum turgidum)
Proline degradation (Triticum urartu)
Proline degradation (Vicia faba var. faba)
Proline degradation (Vigna angularis)
Proline degradation (Vigna radiata)
Proline degradation (Vigna unguiculata)
Proline degradation (Vitis vinifera)
Proline degradation (Zea mays)
Proline degradation (Zea mays ver5)
Proline degradation (Zoysia japonica)
Cross References
RiceCyc