Plant Reactome Pathway Database - Plant Reactome Pathway Database

Sphingolipid metabolism

Stable Identifier

R-OSA-1119325

Type

Pathway

Species

Oryza sativa

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

pathway100864

Locations in the PathwayBrowser

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Summation

Sphingolipids compose ?40% of the lipids of the plasma membrane and are also abundant in other endomembranes. There are three main types of sphingolipids: ceramides, sphingomyelins, and glycosphingolipids. Ceramides are the most simple sphingolipids, composed of only the sphingoid base and a fatty acid. Sphingomyelins are composed of a ceramide bound to a charged head group, usually phosphocholine. Glycosphingolipids are composed of a ceramide with attached mono- or oligosaccharide moieties. Sphingolipid biosynthesis starts in the endoplasmic reticulum (ER). L-serine is condensed with palmitoyl-CoA to generate a sphingoid long-chain base (LCB) that is reduced and then N-acylated to form ceramide. Ceramides are substrates for the production of complexs sphingolipids, including inositol phosphorylceramide (IPC), and glucosylceramide. Functional genomics of sphingolipid metabolism genes show that these molecules have essential functions in plant growth, development, and stress responses (Ishikawa et al., 2016).

Data source: RiceCyc

Literature References

PubMed ID	Title	Journal	Year
19001565	An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis	Plant Cell	2008
17194770	The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase	Plant Cell	2006
18978071	Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis	Plant Physiol.	2009
19816144	Unraveling the roles of sphingolipids in plant innate immunity	Plant Signal Behav	2009
27454201	Molecular characterization and targeted quantitative profiling of the sphingolipidome in rice	Plant J.	2016
11297741	Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana	FEBS Lett.	2001
18218968	Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis	Plant Physiol.	2008
27990147	Molecular Characterization of Rice OsLCB2a1 Gene and Functional Analysis of its Role in Insect Resistance	Front Plant Sci	2016
25113543	Molecular characterization of rice sphingosine-1-phosphate lyase gene OsSPL1 and functional analysis of its role in disease resistance response	Plant Cell Rep.	2014
23025549	Arabidopsis mutants of sphingolipid fatty acid ?-hydroxylases accumulate ceramides and salicylates	New Phytol.	2012
21666002	Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis	Plant Cell	2011
21421810	Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana	Plant Cell	2011
11726713	Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis	Plant Cell Physiol.	2001
25806037	Deciphering the link between salicylic acid signaling and sphingolipid metabolism	Front Plant Sci	2015
14563678	Ceramides modulate programmed cell death in plants	Genes Dev.	2003
14572652	Formation of glucosylceramide and sterol glucoside by a UDP-glucose-dependent glucosylceramide synthase from cotton expressed in Pichia pastoris	FEBS Lett.	2003
18557834	Involvement of sphingosine kinase in plant cell signalling	Plant J.	2008